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KMID : 0880520160520010059
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Chonnam Medical Journal
2016 Volume.52 No. 1 p.59 ~ p.63
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Association of APOE Genotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies
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Kim Sun-A
Kweon Sun-Seog
Choi Jin-Su
Rhee Jung-Ae
Lee Young-Hoon
Nam Hae-Sung
Jeong Seul-Ki
Park Kyeong-Soo
Ryu So-Yeon
Choi Seong-Woo
Kim Hee-Nam
Song Hye-Rim
Oh Su-Hyun
Jane A. Cauley
Shin Min-Ho
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Abstract
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Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian populations. We studied the relationship of the APOE gene polymorphism and BMD in two large population-based studies. The datasets included the Dong-gu Study (3575 men and 5335 women) and the Namwon Study (2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chain reaction?restriction fragment length polymorphism. The APOE genotypes were classified into APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 and E4/E4). The genotype distribution of the study population was in Hardy-Weinberg equilibrium. There were no significant differences among APOE genotype groups in lumbar and femoral neck BMD in either cohort. Our data do not support the hypothesis that the APOE genotype is associated with BMD.
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KEYWORD
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Apolipoprotein E, Polymorphism, genetic, Bone density
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